Foglight can monitor .NET applications, you can see additional info and list of features here
http://www.quest.com/foglight-for-net/
You can see a full list of what foglight can monitor here
http://www.quest.com/foglight/ keep in mind that we can extend the monitoring with customizations and scripts.
With monitoring web requests we can do application related monitoring or just general web traffic to web server, you can get additional info and list of features here http://www.quest.com/foglight-end-user/
Hope this helps.
Golan